A liposomal clodronate is an experimental treatment for certain autoimmune diseases. So far it has been used on mice, but the results are positive and promising. While the terminology used to describe what clodronate liposomes do can be complex and use difficult jargon, it is possible to describe its usage in simpler terms.
A disease called Autoimmune Hemolytic Anemia, or AIHA for short, affects people by destroying their red blood cells. People need red blood cells to live. They distribute oxygen from the lungs to all of the cells in your body. When AIHA strikes, the disease instructs some of your white blood cells, known as macrophages, to attack your own body.
The word macrophage is made up of two Greek words: macro- which means large, and phage, which means to eat. So these 'big eaters' begin consuming the red blood cells in the sick person's body. This is bad because the fewer red blood cells you have, the more difficult it is for your body to get oxygen.
Therefore scientists came up with a group of chemicals to stop these big eaters from consuming red blood cells. These chemicals are called liposomal clodronates. These clodronates use a Trojan effect, the name of which comes from the Trojan horse which, according to mythology, was used to sneak soldiers into the city of Troy. The clodronates sneak chemicals into the macrophages which destroys them inside out. They then no longer eat the red blood cells and your body gets the oxygen it needs.
This solution is only a patch, though. It does not fix the whole problem. Macrophages are not bad guys. When they are healthy, they are the main ones that protect your body against diseases. They are only dangerous when they have been taken over by AIHA.
When someone gets a cold, they take an antihistamine in order to treat the symptoms of their cold so that they can rest and recover from the disease itself. That is like what liposomal clodronate does. It lets doctors treat the symptoms of AIHA so that they then have time to look for and stop the disease itself.
A disease called Autoimmune Hemolytic Anemia, or AIHA for short, affects people by destroying their red blood cells. People need red blood cells to live. They distribute oxygen from the lungs to all of the cells in your body. When AIHA strikes, the disease instructs some of your white blood cells, known as macrophages, to attack your own body.
The word macrophage is made up of two Greek words: macro- which means large, and phage, which means to eat. So these 'big eaters' begin consuming the red blood cells in the sick person's body. This is bad because the fewer red blood cells you have, the more difficult it is for your body to get oxygen.
Therefore scientists came up with a group of chemicals to stop these big eaters from consuming red blood cells. These chemicals are called liposomal clodronates. These clodronates use a Trojan effect, the name of which comes from the Trojan horse which, according to mythology, was used to sneak soldiers into the city of Troy. The clodronates sneak chemicals into the macrophages which destroys them inside out. They then no longer eat the red blood cells and your body gets the oxygen it needs.
This solution is only a patch, though. It does not fix the whole problem. Macrophages are not bad guys. When they are healthy, they are the main ones that protect your body against diseases. They are only dangerous when they have been taken over by AIHA.
When someone gets a cold, they take an antihistamine in order to treat the symptoms of their cold so that they can rest and recover from the disease itself. That is like what liposomal clodronate does. It lets doctors treat the symptoms of AIHA so that they then have time to look for and stop the disease itself.
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